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KMID : 0043320080310070834
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Archives of Pharmacal Research
2008 Volume.31 No. 7 p.834 ~ p.837
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Synthesis and Hypnotic Activities of N-Cbz--aminoglutarimidooxy Carboxylate Derivatives
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Byun Ae-Sun
Park Jin-Yup
Moon Kyung-Hee
Park Min-Soo
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Abstract
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Typical hypnotic drugs, such as barbitals and glutethimide, have a cyclic imide (-CO-NH-CO-) moiety. The N-Cbz--aminoglutarimidooxy carboxylate derivatives, which we previously showed exhibit moderate anticonvulsant activities, also have a cyclic imide (-CO-N-CO-) moiety. This structural similarity prompted us to examine the hypnotic activities of the N-Cbz--aminoglutarimidooxy carboxylate derivatives, and we describe their moderate hypnotic activities here.
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KEYWORD
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Glutethimide, Barbitals, Glutarimide, Hypnotic activity, Anticonvulsant, Cyclic imide
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